Angiotensin (1-7)
Overview
Angiotensin (1-7) is a seven-amino acid peptide component of the renin-angiotensin system formed through cleavage of angiotensin II by ACE2 or from angiotensin I by endopeptidases. It binds to the Mas receptor to produce vasodilation, anti-proliferative, anti-fibrotic, and anti-inflammatory effects that generally oppose the actions of angiotensin II.
Mechanism of Action
This counter-regulatory arm of the renin-angiotensin system represents a therapeutic target in hypertension, heart failure, and renal disease.
Research Summary & Key Findings
Preclinical studies have demonstrated that angiotensin (1-7) reduces blood pressure, attenuates cardiac remodeling, and improves endothelial function in animal models of cardiovascular disease. Clinical development has been limited by the peptide's short half-life, though modified analogues and oral formulations are under investigation without published phase 3 trial results.
Clinical Status
Angiotensin (1-7) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed — "Angiotensin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Angiotensin"
Registered interventional and observational studies, including status and phase.
- PubChem — "Angiotensin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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