Recovery · In Clinical Trials
Dalargin
No lawful US pathway
01 · Overview
Dalargin is a synthetic hexapeptide analogue of leucine-enkephalin, D-Ala2, Leu5, Arg6-enkephalin (PMID 18488902). It acts on opioid receptors, with different studies attributing its effects to mu-opioid (PMID 18488902) or delta-opioid receptors (PMID 23651617).
It has been described as having gastric antisecretory and cytoprotective properties (PMID 1811815).
02 · Research summary & key findings
Dalargin was commonly used in the former USSR for peptic ulcer disease, but in a randomized, double-blind trial in duodenal ulcer, misoprostol was significantly more effective than intramuscular dalargin at healing ulcers (PMID 1811815). Russian-language clinical reports have described its use in pancreatitis (PMID 1279830), and animal studies report organ-protective effects such as reduced gentamicin kidney injury (PMID 23651617). Most evidence is from Soviet and Russian studies, and it is not approved in the United States.
03 · Regulatory status
Dalargin is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
No lawful pathway today
Dalargin is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so we do not sell it and will not book a consultation for it. That can change: in 2026 FDA began reviewing several peptides for compounding. If you are working on the goal it is studied for, a licensed clinician can tell you what is lawfully available, which may be something else.
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Looking for a lawful, clinician-prescribed option for injury recovery and tissue repair?
Dalargin is still in clinical trials, is not FDA-approved, and has no lawful US compounding pathway, so we do not offer it and no clinician we work with will prescribe it. Products sold online as “research chemicals” are not made or tested to the standards required of medicines. If you are working on injury recovery and tissue repair, a licensed clinician can tell you at a free consultation whether an FDA-approved or lawfully compounded treatment fits you, or whether nothing does.
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04 · Administration routes
- Intravenous
- Intramuscular injection
References
- [1][Dalargin in the therapy of the exacerbations of chronic pancreatitis] Ter Arkh, 1992. PMID 1279830
- [2]Misoprostol and dalargin for the inpatient treatment of duodenal ulcer in the USSR J Assoc Acad Minor Phys, 1991. PMID 1811815
- [3][Cardiovascular effects of D-ALA2, LEU5, ARG6-enkephalin (dalargin) are mediated by peripheral mu-opioid receptor activation] Eksp Klin Farmakol, 2008. PMID 18488902
- [4]Nephroprotective effect of GSK-3β inhibition by lithium ions and δ-opioid receptor agonist dalargin on gentamicin-induced nephrotoxicity Toxicol Lett, 2013. PMID 23651617
Primary literature
- PubMed: "Dalargin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Dalargin"
Registered interventional and observational studies, including status and phase.
- PubChem: "Dalargin"
Chemical structure, molecular properties, and bioactivity data.
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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed. Clinicians: join the network.