Serelaxin (Relaxin-2)
Overview
Serelaxin is a recombinant form of human relaxin-2, a naturally occurring peptide hormone composed of two chains linked by disulfide bonds. It acts via the relaxin family peptide receptor 1 (RXFP1) to promote vasodilation, inhibit fibrosis, and modulate hemodynamics.
Mechanism of Action
The therapeutic rationale targets acute heart failure by improving renal perfusion and reducing vascular resistance.
Research Summary & Key Findings
The RELAX-AHF trial (Lancet, 2013) demonstrated improved dyspnea and reduced 180-day mortality in acute heart failure patients, but the subsequent RELAX-AHF-2 trial (JAMA, 2017) failed to confirm a mortality or cardiovascular event benefit. The FDA did not approve serelaxin, and further development was discontinued.
Clinical Status
Serelaxin (Relaxin-2) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed — "Serelaxin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Serelaxin"
Registered interventional and observational studies, including status and phase.
- PubChem — "Serelaxin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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