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Serelaxin (Relaxin-2)
Overview
Serelaxin is a recombinant form of human relaxin-2, a naturally occurring peptide hormone composed of two chains linked by disulfide bonds. It acts via the relaxin family peptide receptor 1 (RXFP1) to promote vasodilation, inhibit fibrosis, and modulate hemodynamics.
Mechanism of Action
The therapeutic rationale targets acute heart failure by improving renal perfusion and reducing vascular resistance.
Research Summary & Key Findings
The RELAX-AHF trial (Lancet, 2013) demonstrated improved dyspnea and reduced 180-day mortality in acute heart failure patients, but the subsequent RELAX-AHF-2 trial (JAMA, 2017) failed to confirm a mortality or cardiovascular event benefit. The FDA did not approve serelaxin, and further development was discontinued.
Clinical Status
Serelaxin (Relaxin-2) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed: "Serelaxin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Serelaxin"
Registered interventional and observational studies, including status and phase.
- PubChem: "Serelaxin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Serelaxin (Relaxin-2) is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.