Hormone · In Clinical Trials
Kisspeptin
No lawful US pathway
01 · Overview
A family of neuropeptides encoded by the KISS1 gene that act as key upstream regulators of the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin activates GPR54 (KISS1R) to stimulate gonadotropin-releasing hormone secretion and subsequent LH and FSH release, and kisspeptin-54, the major circulating form in humans, potently stimulates reproductive hormone secretion (PMID 25036713).
It plays a critical role in puberty onset and fertility, and is not FDA approved.
02 · Research summary & key findings
Loss-of-function mutations in the kisspeptin receptor GPR54 cause hypogonadotropic hypogonadism with absent puberty (PMID 14573733). A single injection of kisspeptin-54 induced egg maturation in women undergoing IVF (Jayasena et al., J Clin Invest, 2014) (PMID 25036713). In a phase 2 trial in women at high risk of OHSS, it triggered oocyte maturation in 95% with no moderate or severe OHSS (PMID 26192876).
03 · Regulatory status
Kisspeptin is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
No lawful pathway today
Kisspeptin is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so we do not sell it and will not book a consultation for it. That can change: in 2026 FDA began reviewing several peptides for compounding. If you are working on the goal it is studied for, a licensed clinician can tell you what is lawfully available, which may be something else.
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Looking for a lawful, clinician-prescribed option for hormone optimization?
Kisspeptin is still in clinical trials, is not FDA-approved, and has no lawful US compounding pathway, so we do not offer it and no clinician we work with will prescribe it. Products sold online as “research chemicals” are not made or tested to the standards required of medicines. If you are working on hormone optimization, a licensed clinician can tell you at a free consultation whether an FDA-approved or lawfully compounded treatment fits you, or whether nothing does.
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04 · Administration routes
- Intravenous
- Subcutaneous injection
References
- [1]The GPR54 gene as a regulator of puberty N Engl J Med, 2003. PMID 14573733
- [2]Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization J Clin Invest, 2014. PMID 25036713
- [3]Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy J Clin Endocrinol Metab, 2015. PMID 26192876
Primary literature
- PubMed: "Kisspeptin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Kisspeptin"
Registered interventional and observational studies, including status and phase.
- PubChem: "Kisspeptin"
Chemical structure, molecular properties, and bioactivity data.
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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed. Clinicians: join the network.