Reproductive · FDA Approved
Cetrorelix (Cetrotide) Analog
FDA-approved
01 · Overview
Cetrorelix is a synthetic decapeptide analogue of gonadotropin-releasing hormone that acts as a competitive GnRH receptor antagonist. By blocking pituitary GnRH receptors it suppresses luteinizing hormone and follicle-stimulating hormone secretion rapidly and without the initial agonist flare seen with GnRH agonists.
This makes it useful in controlled ovarian stimulation, where preventing a premature LH surge protects the timing of oocyte retrieval. Cetrotide was approved under NDA 021197 and generic cetrorelix acetate products are also listed in the FDA drug approval database.
02 · Research summary & key findings
Cetrorelix acetate was approved by the FDA in August 2000 for prevention of premature LH surges in women undergoing controlled ovarian stimulation, according to the FDA drug approval database. A Cochrane network meta-analysis of 338 randomized trials in 59,086 women found that in women with a predicted normal response, short GnRH antagonist protocols probably result in little or no difference in live birth or ongoing pregnancy compared with long GnRH agonist protocols, and may reduce ovarian hyperstimulation syndrome (PMID 40590303). The same analysis found antagonist protocols may yield slightly fewer oocytes than long agonist protocols (PMID 40590303).
03 · Regulatory status
Cetrorelix (Cetrotide) Analog has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.
Cetrorelix (Cetrotide) Analog is an FDA-approved medicine prescribed for the conditions on its label. It is not part of our intake, so we do not propose protocols for it. If you think it may be relevant to you, talk to your own doctor. How to ask your doctor.
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04 · Administration routes
- Subcutaneous injection
References
- [1]Controlled ovarian stimulation protocols for assisted reproduction: a network meta-analysis Cochrane Database Syst Rev, 2025. PMID 40590303
Primary literature
- PubMed: "Cetrorelix Analog"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Cetrorelix Analog"
Registered interventional and observational studies, including status and phase.
- PubChem: "Cetrorelix Analog"
Chemical structure, molecular properties, and bioactivity data.
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