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Efinopegdutide
Overview
Efinopegdutide is a long-acting dual agonist of the GLP-1 and glucagon receptors, utilizing PEGylation to extend half-life and enable once-weekly dosing. The compound combines GLP-1-mediated glycemic control and appetite reduction with glucagon-driven energy expenditure and hepatic fat mobilization.
Mechanism of Action
It is under investigation for obesity and metabolic dysfunction-associated steatohepatitis.
Research Summary & Key Findings
Phase 2 trials in adults with non-alcoholic steatohepatitis (now termed metabolic dysfunction-associated steatohepatitis) have demonstrated reductions in liver fat and body weight. Results published in hepatology journals in 2021 and 2022 supported progression into later-stage development. Phase 3 trials are ongoing to assess histological endpoints and cardiovascular outcomes.
Clinical Status
Efinopegdutide is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
Administration Routes
References
Primary literature
- PubMed: "Efinopegdutide"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Efinopegdutide"
Registered interventional and observational studies, including status and phase.
- PubChem: "Efinopegdutide"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Efinopegdutide is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
Tell me if the status changes
One email, only if this compound's regulatory standing actually moves. Not a newsletter, not a sales sequence.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.