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Pinealon
Overview
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed as part of the Khavinson peptide bioregulator series, designed to mimic endogenous short peptides that regulate gene expression in neural tissues. It is hypothesized to interact with chromatin and influence transcription of genes involved in neuronal survival and plasticity.
Mechanism of Action
Pinealon has been studied primarily in the context of age-related cognitive decline and neurodegenerative models.
Research Summary & Key Findings
Preclinical studies in rodent models of aging and neurodegeneration have reported improvements in memory, motor coordination, and markers of neuronal health, with data appearing in Russian pharmacology journals. Human clinical evidence remains sparse, with small observational studies suggesting subjective cognitive benefit in elderly populations. Peer-reviewed replication and placebo-controlled trials in international journals are lacking.
Clinical Status
Pinealon is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed: "Pinealon"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Pinealon"
Registered interventional and observational studies, including status and phase.
- PubChem: "Pinealon"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Pinealon is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
Tell me if the status changes
One email, only if this compound's regulatory standing actually moves. Not a newsletter, not a sales sequence.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.