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The compound database

Peptide Database

264 therapeutic peptides with research summaries, clinical findings, and regulatory status. Every claim is cited.

FDA-approved
90
FDA-approved
Awaiting FDA
8
Awaiting FDA
No lawful pathway
166
No lawful pathway
1–29 of 29 · MetabolicClear filters
  1. 001

    Semaglutide (Ozempic/Wegovy)

    A glucagon-like peptide-1 receptor agonist (GLP-1 RA) that differs from native GLP-1 by two amino acid substitutions (about 94% sequence identity) plus a fatty…

    Metabolic · FDA Approved · Subcutaneous injection (weekly), Oral (daily - Rybelsus)

    FDA-approved
  2. 002

    Tirzepatide (Mounjaro/Zepbound)

    A once-weekly dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. Tirzepatide activates both incretin pathways, and in…

    Metabolic · FDA Approved · Subcutaneous injection (weekly)

    FDA-approved
  3. 003

    Retatrutide

    An investigational once-weekly triple hormone receptor agonist targeting GIP, GLP-1, and glucagon receptors, not yet FDA approved. The glucagon receptor…

    Metabolic · In Clinical Trials · Subcutaneous injection (weekly)

    No lawful pathway
  4. 004

    AOD-9604

    A modified fragment of the C-terminus of human growth hormone, consisting of hGH residues 177-191 with an added N-terminal tyrosine (16 amino acids). AOD-9604…

    Metabolic · Investigational · Subcutaneous injection, Oral

    Awaiting FDA
  5. 005

    Liraglutide (Saxenda/Victoza)

    A GLP-1 receptor agonist with 97% homology to native GLP-1, modified with a 16-carbon fatty acid chain that binds albumin and protects against DPP-4…

    Metabolic · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  6. 006

    Exenatide (Byetta/Bydureon)

    A synthetic version of exendin-4, a 39-amino acid peptide originally isolated from the venom of the Gila monster lizard (Heloderma suspectum). Exenatide shares…

    Metabolic · FDA Approved · Subcutaneous injection (twice daily or weekly extended-release)

    FDA-approved
  7. 007

    Glucagon

    A 29-amino acid peptide hormone produced by alpha cells of the pancreatic islets of Langerhans. Glucagon acts on the liver via the glucagon receptor (GCGR), a…

    Metabolic · FDA Approved · Subcutaneous injection, Intramuscular injection, Intranasal

    FDA-approved
  8. 008

    Pramlintide (Symlin)

    A synthetic analog of amylin (islet amyloid polypeptide), a 37-amino acid peptide hormone co-secreted with insulin from pancreatic beta cells. Pramlintide has…

    Metabolic · FDA Approved · Subcutaneous injection (before meals)

    FDA-approved
  9. 009

    Dulaglutide (Trulicity)

    A long-acting GLP-1 receptor agonist consisting of a GLP-1 analog fused to a modified human IgG4 Fc fragment, a design that retained full receptor activity…

    Metabolic · FDA Approved · Subcutaneous injection (weekly)

    FDA-approved
  10. 010

    Lixisenatide (Adlyxin)

    A selective GLP-1 receptor agonist derived from exendin-4 with a modified C-terminal tail containing six lysine residues. Lixisenatide increases…

    Metabolic · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  11. 011

    Setmelanotide (Imcivree)

    A cyclic peptide melanocortin-4 receptor (MC4R) agonist designed to restore MC4R signaling in patients with obesity caused by genetic defects in the…

    Metabolic · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  12. 012

    Orforglipron

    Orforglipron is a non-peptide, oral small-molecule glucagon-like peptide-1 receptor (GLP-1R) agonist developed as an alternative to injectable GLP-1 drugs. It…

    Metabolic · FDA Approved · Oral

    FDA-approved
  13. 013

    Mazdutide

    Mazdutide is a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist given as a once-weekly subcutaneous peptide injection. By co-activating both…

    Metabolic · In Clinical Trials · Subcutaneous injection

    No lawful pathway
  14. 014

    Survodutide

    Survodutide is a dual agonist of the glucagon and glucagon-like peptide-1 (GLP-1) receptors, given as a once-weekly subcutaneous peptide injection. The…

    Metabolic · In Clinical Trials · Subcutaneous injection

    No lawful pathway
  15. 015

    CagriSema

    CagriSema is a once-weekly combination of cagrilintide, a long-acting amylin analog, and semaglutide, a GLP-1 receptor agonist, both delivered as peptides by…

    Metabolic · In Clinical Trials · Subcutaneous injection

    No lawful pathway
  16. 016

    Amycretin

    Amycretin is a single-molecule (unimolecular) agonist of both the GLP-1 receptor and the amylin receptor, developed by Novo Nordisk for obesity in both oral…

    Metabolic · In Clinical Trials · Subcutaneous injection

    No lawful pathway
  17. 017

    Efinopegdutide

    Efinopegdutide (MK-6024) is a long-acting dual agonist of the GLP-1 and glucagon receptors given once weekly by subcutaneous injection. The compound combines…

    Metabolic · In Clinical Trials · Subcutaneous injection

    No lawful pathway
  18. 018

    Danuglipron

    Danuglipron (PF-06882961) is an oral, non-peptide small-molecule agonist of the GLP-1 receptor that was developed for type 2 diabetes and obesity. It mimics…

    Metabolic · Investigational · Oral

    No lawful pathway
  19. 019

    Ecnoglutide

    Ecnoglutide (XW003) is a long-acting GLP-1 receptor agonist peptide developed by Sciwind Biosciences for once-weekly subcutaneous use, with an oral tablet form…

    Metabolic · In Clinical Trials · Subcutaneous injection

    No lawful pathway
  20. 020

    Cotadutide

    Cotadutide (MEDI0382) is a dual agonist of the GLP-1 and glucagon receptors formulated as a peptide for once-daily subcutaneous injection. It was designed to…

    Metabolic · Investigational · Subcutaneous injection

    No lawful pathway
  21. 021

    Glepaglutide

    Glepaglutide is a long-acting GLP-2 receptor agonist peptide developed for the treatment of short bowel syndrome (SBS), designed as a ready-to-use injection.…

    Metabolic · In Clinical Trials · Subcutaneous injection

    No lawful pathway
  22. 022

    Apraglutide

    Apraglutide is a long-acting glucagon-like peptide-2 (GLP-2) receptor agonist given once weekly by subcutaneous injection, designed to promote intestinal…

    Metabolic · In Clinical Trials · Subcutaneous injection

    No lawful pathway
  23. 023

    Teduglutide (Gattex)

    Teduglutide is a recombinant analogue of human glucagon-like peptide-2 (GLP-2) comprising 33 amino acids with a single amino acid substitution that confers…

    Metabolic · FDA Approved · Subcutaneous injection

    FDA-approved
  24. 024

    Beinaglutide

    Beinaglutide is a recombinant human GLP-1 (rhGLP-1) used in China as a treatment for type 2 diabetes. Unlike long-acting GLP-1 analogues, it is short-acting…

    Metabolic · In Clinical Trials · Subcutaneous injection

    No lawful pathway
  25. 025

    Albiglutide (Tanzeum)

    Albiglutide is a GLP-1 receptor agonist made of modified human GLP-1 sequences fused to human albumin, giving it an elimination half-life of about 5 days that…

    Metabolic · FDA Approved · Subcutaneous injection

    FDA-approved
  26. 026

    Taspoglutide

    Taspoglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist derived from human GLP-1 with amino acid substitutions designed to resist…

    Metabolic · Investigational · Subcutaneous injection

    No lawful pathway
  27. 027

    Pemvidutide

    Pemvidutide (ALT-801) is a dual receptor agonist targeting the glucagon-like peptide-1 (GLP-1) and glucagon receptors, given once weekly by subcutaneous…

    Metabolic · In Clinical Trials · Subcutaneous injection

    No lawful pathway
  28. 028

    Cagrilintide

    Cagrilintide is a long-acting amylin analogue given once weekly by subcutaneous injection and developed for weight management. Amylin is a 37-amino-acid…

    Metabolic · In Clinical Trials · Subcutaneous injection

    No lawful pathway
  29. 029

    Enlicitide

    Enlicitide (enlicitide decanoate, formerly MK-0616) is an oral macrocyclic peptide that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9)…

    Metabolic · FDA Approved · Oral

    FDA-approved

Index · all 264 peptides, A–Z

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