Eptifibatide (Integrilin)
Overview
A synthetic cyclic heptapeptide modeled after the KGD (Lys-Gly-Asp) disintegrin sequence found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri).
Mechanism of Action
Eptifibatide is a potent, reversible glycoprotein IIb/IIIa receptor antagonist that blocks the final common pathway of platelet aggregation by preventing fibrinogen and von Willebrand factor binding to activated platelets.
Research Summary & Key Findings
FDA-approved for acute coronary syndrome and percutaneous coronary intervention. PURSUIT trial showed 1.5% absolute reduction in death or MI at 30 days in ACS patients (NEJM, 1998). ESPRIT trial demonstrated 37% relative reduction in death, MI, or urgent target vessel revascularization at 48 hours in PCI patients. Short half-life (2.5 hours) allows rapid recovery of platelet function after discontinuation.
Clinical Status
Eptifibatide (Integrilin) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.
Administration Routes
References
Primary literature
- PubMed — "Eptifibatide"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Eptifibatide"
Registered interventional and observational studies, including status and phase.
- PubChem — "Eptifibatide"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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