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MetabolicFDA Approved

Lixisenatide (Adlyxin)

Subcutaneous injection (daily)
Written by Peptide Association Editorial TeamMedically reviewed by Ian Justl Ellis, MD, CPTLast reviewed Editorial policy

Overview

A selective GLP-1 receptor agonist derived from exendin-4 with a modified C-terminal tail containing six lysine residues. Lixisenatide has a half-life of approximately 3 hours and primarily reduces postprandial glucose through potent delay of gastric emptying rather than fasting glucose reduction.

Mechanism of Action

It is designed for once-daily use as an add-on to basal insulin therapy in type 2 diabetes.

Research Summary & Key Findings

FDA-approved in 2016 for type 2 diabetes. GetGoal clinical trial program demonstrated effective postprandial glucose control. ELIXA cardiovascular outcomes trial confirmed cardiovascular safety. Available as a fixed-ratio combination with insulin glargine (Soliqua 100/33).

Clinical Status

FDA Approved

Lixisenatide (Adlyxin) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection (daily)

References

Primary literature

Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.