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LongevityResearch Phase

Epithalon (Epitalon)

Subcutaneous injection, Intravenous
Written by Peptide Association Editorial TeamMedically reviewed by Ian Justl Ellis, MD, CPTLast reviewed Editorial policy

Overview

A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural epithalamin peptide produced by the pineal gland. Epithalon activates telomerase, the enzyme responsible for maintaining telomere length, thereby potentially extending cellular replicative capacity.

Mechanism of Action

It also stimulates melatonin production and modulates neuroendocrine system function associated with aging.

Research Summary & Key Findings

Studies by Khavinson et al. demonstrated telomerase activation in human somatic cells and elongation of telomeres. Rodent studies showed increased lifespan by 13-25%. Clinical observations in elderly patients suggested improvements in melatonin production and immune function biomarkers.

Clinical Status

Research Phase

Epithalon (Epitalon) is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.

Administration Routes

Subcutaneous injectionIntravenous

References

Primary literature

Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.