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RenalFDA Approved

Desmopressin (DDAVP)

Intranasal, Oral, Subcutaneous injection, Intravenous
Written by Peptide Association Editorial TeamMedically reviewed by Ian Justl Ellis, MD, CPTLast reviewed Editorial policy

Overview

A synthetic analog of vasopressin with enhanced V2 receptor selectivity and minimal V1a vasopressor activity. Desmopressin has a deaminated cysteine at position 1 and D-arginine at position 8, increasing its antidiuretic potency 10-fold while largely eliminating the hypertensive effects of native vasopressin.

Mechanism of Action

Its prolonged half-life of 2-4 hours (vs. 10-20 minutes for vasopressin) allows convenient dosing for chronic conditions.

Research Summary & Key Findings

FDA-approved for central diabetes insipidus, primary nocturnal enuresis, hemophilia A, and von Willebrand disease (type 1). Releases stored von Willebrand factor and factor VIII from endothelial Weibel-Palade bodies. DDAVP challenge test used to assess coagulation factor response pre-procedurally. Risk of hyponatremia with fluid overloading requires careful monitoring, especially in elderly patients.

Clinical Status

FDA Approved

Desmopressin (DDAVP) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

IntranasalOralSubcutaneous injectionIntravenous

References

Primary literature

Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.