Splenopentin
Overview
Splenopentin is a synthetic pentapeptide (Arg-Lys-Glu-Val-Tyr) corresponding to residues 32 to 36 of the splenic hormone splenin. It modulates immune cell function by enhancing macrophage activity and stimulating antibody production.
Mechanism of Action
The therapeutic rationale is to provide targeted immune enhancement without whole-organ extract variability.
Research Summary & Key Findings
Preclinical studies in rodents demonstrated increased phagocytic activity and antibody titers following splenopentin administration. There is limited published clinical trial data, and the peptide remains primarily a research tool for understanding splenic immunomodulation.
Clinical Status
Splenopentin is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed — "Splenopentin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Splenopentin"
Registered interventional and observational studies, including status and phase.
- PubChem — "Splenopentin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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