Peptide DatabasePage 3

265 therapeutic peptides with research summaries, clinical findings, and regulatory status.

Showing 73–108 of 265
GastrointestinalFDA Approved

Octreotide (Sandostatin)

A synthetic octapeptide analog of somatostatin with a substantially longer half-life (90 minutes IV, 6 hours subcutaneous vs. 2 minutes for native…

Subcutaneous injection, Intramuscular injection (LAR), Intravenous
GastrointestinalFDA Approved

Lanreotide (Somatuline Depot)

A synthetic octapeptide analog of somatostatin with high affinity for SSTR2 and moderate affinity for SSTR5 receptors. Lanreotide is formulated as a…

Deep subcutaneous injection (monthly)
GastrointestinalFDA Approved

Pasireotide (Signifor)

A multireceptor-targeted somatostatin analog with high binding affinity for SSTR1, SSTR2, SSTR3, and SSTR5, particularly notable for its 40-fold…

Subcutaneous injection (twice daily), Intramuscular injection (monthly LAR)
GastrointestinalFDA Approved

Plecanatide (Trulance)

A synthetic 16-amino acid peptide structurally related to uroguanylin, an endogenous intestinal peptide that regulates fluid and electrolyte…

Oral
GastrointestinalFDA Approved

Linaclotide (Linzess)

A synthetic 14-amino acid peptide structurally related to the heat-stable enterotoxin of Escherichia coli and the endogenous peptide guanylin.…

Oral
GastrointestinalFDA Approved

Secretin

A 27-amino acid peptide hormone produced by S-cells of the duodenal and jejunal mucosa in response to acidic chyme entering the small intestine.…

Intravenous
GastrointestinalIn Clinical Trials

Larazotide

A synthetic octapeptide derived from Vibrio cholerae zonula occludens toxin that acts as a tight junction regulator. Larazotide acetate modulates…

Oral
PainFDA Approved

Ziconotide (Prialt)

A synthetic 25-amino acid peptide identical to omega-conotoxin MVIIA, a neurotoxin found in the venom of the marine cone snail Conus magus.…

Intrathecal infusion
PainFDA Approved

Difelikefalin (Korsuva)

A selective kappa-opioid receptor (KOR) agonist peptide that does not cross the blood-brain barrier, providing peripheral analgesia and anti-pruritic…

Intravenous (post-dialysis)
PainIn Clinical Trials

ARA-290

A synthetic 11-amino acid peptide derived from the structure of erythropoietin (EPO) that selectively activates the innate repair receptor (IRR), a…

Subcutaneous injection, Intravenous
DermatologyFDA Approved

Afamelanotide (Scenesse)

A synthetic 13-amino acid analog of alpha-melanocyte-stimulating hormone (alpha-MSH) with a substitution of norleucine at position 4 that confers…

Subcutaneous implant
DiagnosticFDA Approved

Pentagastrin

A synthetic pentapeptide containing the C-terminal tetrapeptide sequence of gastrin (Trp-Met-Asp-Phe-NH2) linked to beta-alanine. Pentagastrin…

Subcutaneous injection, Intramuscular injection
ImmuneFDA Approved

Icatibant (Firazyr)

A synthetic decapeptide bradykinin B2 receptor antagonist containing five non-natural amino acids for enhanced stability and receptor selectivity.…

Subcutaneous injection
PainResearch Phase

Palmitoylethanolamide (PEA)

An endogenous fatty acid amide belonging to the N-acylethanolamine family, naturally produced by cells in response to tissue damage and inflammation.…

Oral
MetabolicIn Clinical Trials

Orforglipron

Orforglipron is a non-peptide, oral small-molecule glucagon-like peptide-1 receptor (GLP-1R) agonist designed to overcome the need for injectable…

Oral
MetabolicIn Clinical Trials

Mazdutide

Mazdutide is a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist delivered as a synthetic peptide. By co-activating both receptors…

Subcutaneous injection
MetabolicIn Clinical Trials

Survodutide

Survodutide is a dual agonist targeting both the glucagon-like peptide-1 (GLP-1) and glucagon receptors, formulated as a peptide for subcutaneous…

Subcutaneous injection
MetabolicIn Clinical Trials

CagriSema

CagriSema is a fixed-ratio combination of cagrilintide, an amylin analog, and semaglutide, a GLP-1 receptor agonist, both delivered as peptides via…

Subcutaneous injection
MetabolicIn Clinical Trials

Amycretin

Amycretin is a dual agonist targeting both the amylin and calcitonin receptors, designed as a peptide therapeutic for obesity. Amylin receptor…

Subcutaneous injection
MetabolicIn Clinical Trials

Efinopegdutide

Efinopegdutide is a long-acting dual agonist of the GLP-1 and glucagon receptors, utilizing PEGylation to extend half-life and enable once-weekly…

Subcutaneous injection
MetabolicIn Clinical Trials

Danuglipron

Danuglipron is an oral, non-peptide small-molecule agonist of the GLP-1 receptor developed to provide convenient daily dosing for type 2 diabetes and…

Oral
MetabolicIn Clinical Trials

Ecnoglutide

Ecnoglutide is a long-acting GLP-1 receptor agonist peptide designed for once-weekly subcutaneous administration. It acts by enhancing…

Subcutaneous injection
MetabolicIn Clinical Trials

Cotadutide

Cotadutide is a dual agonist of the GLP-1 and glucagon receptors formulated as a peptide for subcutaneous injection. It is designed to harness…

Subcutaneous injection
MetabolicIn Clinical Trials

Glepaglutide

Glepaglutide is a long-acting GLP-2 receptor agonist peptide developed for the treatment of short bowel syndrome. GLP-2 promotes intestinal growth…

Subcutaneous injection
MetabolicIn Clinical Trials

Apraglutide

Apraglutide is a long-acting glucagon-like peptide-2 (GLP-2) receptor agonist designed to promote intestinal growth and improve absorption in…

Subcutaneous injection
MetabolicFDA Approved

Teduglutide (Gattex)

Teduglutide is a recombinant analogue of human glucagon-like peptide-2 (GLP-2) comprising 33 amino acids with a single amino acid substitution that…

Subcutaneous injection
MetabolicFDA Approved

Beinaglutide

Beinaglutide is a recombinant glucagon-like peptide-1 (GLP-1) receptor agonist engineered with structural modifications to prolong plasma half-life…

Subcutaneous injection
MetabolicFDA Approved

Albiglutide (Tanzeum)

Albiglutide is a GLP-1 receptor agonist consisting of a tandem repeat of modified human GLP-1 sequences fused to human albumin, creating a protein of…

Subcutaneous injection
MetabolicInvestigational

Taspoglutide

Taspoglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist derived from human GLP-1 with amino acid substitutions designed to…

Subcutaneous injection
MetabolicIn Clinical Trials

Pemvidutide

Pemvidutide is a dual receptor agonist targeting both glucagon-like peptide-1 (GLP-1) and glucagon receptors, designed to combine the insulinotropic…

Subcutaneous injection
MetabolicIn Clinical Trials

Cagrilintide

Cagrilintide is a long-acting amylin analogue engineered with structural modifications to extend half-life and enable once-weekly dosing for the…

Subcutaneous injection
MetabolicInvestigational

Enlicitide

Enlicitide is an investigational peptide agonist designed to modulate metabolic pathways involved in energy balance and glucose homeostasis. Limited…

Subcutaneous injection
HormoneFDA Approved

Capromorelin (Entyce)

Capromorelin is a selective ghrelin receptor agonist, or growth hormone secretagogue, that mimics the endogenous peptide hormone ghrelin by binding…

Oral
HormoneFDA Approved

Anamorelin (Adlumiz)

Anamorelin is an orally active selective ghrelin receptor agonist designed to stimulate appetite and promote anabolic processes by mimicking…

Oral
HormoneInvestigational

Relamorelin

Relamorelin is a synthetic pentapeptide ghrelin receptor agonist designed to stimulate growth hormone secretion and promote gastric motility. It…

Subcutaneous injection
HormoneResearch Phase

Mod GRF 1-29 (CJC-1295 no DAC)

Modified GRF 1-29 is a synthetic analogue of growth hormone releasing hormone (GHRH) comprising 29 amino acids with four amino acid substitutions to…

Subcutaneous injection

All 265 peptides

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