Peptide DatabasePage 2

265 therapeutic peptides with research summaries, clinical findings, and regulatory status.

Showing 37–72 of 265
CognitiveFDA Approved

Semax

A synthetic heptapeptide analog of the ACTH(4-7) fragment (Met-Glu-His-Phe-Pro-Gly-Pro) with nootropic and neuroprotective properties. Semax…

Intranasal
CognitiveInvestigational

Selank

A synthetic analog of the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with an added Pro-Gly-Pro sequence for stability. Selank exhibits…

Intranasal
CognitiveInvestigational

Cerebrolysin

A porcine brain-derived peptide preparation consisting of low-molecular-weight neuropeptides and free amino acids that mimic the action of endogenous…

Intravenous, Intramuscular injection
CognitiveResearch Phase

P21 (Peptide)

A small synthetic peptide derived from the active region of ciliary neurotrophic factor (CNTF) designed to promote neurogenesis and synaptic…

Subcutaneous injection, Intranasal
LongevityResearch Phase

Epithalon (Epitalon)

A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural epithalamin peptide produced by the pineal gland. Epithalon activates telomerase, the…

Subcutaneous injection, Intravenous
LongevityResearch Phase

MOTS-c

A mitochondrial-derived peptide encoded by the 12S rRNA gene of mitochondrial DNA. MOTS-c is a 16-amino acid peptide that acts as an exercise mimetic…

Subcutaneous injection
LongevityResearch Phase

Humanin

A 24-amino acid mitochondrial-derived peptide encoded within the 16S rRNA region of mitochondrial DNA. Humanin exerts cytoprotective and…

Subcutaneous injection, Intravenous
LongevityIn Clinical Trials

NAD+ Precursors (NMN)

Nicotinamide mononucleotide (NMN) is a direct biosynthetic precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular…

Oral, Intravenous, Sublingual
LongevityIn Clinical Trials

SS-31 (Elamipretide)

A mitochondria-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that selectively concentrates in the inner mitochondrial membrane by binding to…

Subcutaneous injection, Intravenous
LongevityResearch Phase

FOXO4-DRI

A D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells. In senescent cells, FOXO4 sequesters p53 away…

Subcutaneous injection, Intravenous
ImmuneInvestigational

Thymalin

A peptide bioregulator originally extracted from bovine thymus gland, consisting of a mixture of polypeptides that modulate immune function. Thymalin…

Intramuscular injection
ImmuneResearch Phase

LL-37

The only human cathelicidin antimicrobial peptide, a 37-amino acid cationic peptide cleaved from the precursor protein hCAP18. LL-37 disrupts…

Subcutaneous injection, Topical
ImmuneInvestigational

VIP (Vasoactive Intestinal Peptide)

A 28-amino acid neuropeptide widely distributed in the central and peripheral nervous systems and immune cells. VIP acts through VPAC1 and VPAC2…

Intranasal, Intravenous, Subcutaneous injection
ImmuneInvestigational

Thymosin Alpha 1 (Zadaxin)

A 28-amino acid peptide originally isolated from thymic tissue (thymosin fraction 5) that serves as a potent immunomodulator. Thymosin alpha 1…

Subcutaneous injection
ImmuneInvestigational

Thymopentin (TP-5)

A synthetic pentapeptide (Arg-Lys-Asp-Val-Tyr) corresponding to residues 32-36 of thymopoietin, a thymic hormone involved in T-cell differentiation.…

Subcutaneous injection, Intramuscular injection
ImmuneResearch Phase

Thymulin

A zinc-containing nonapeptide (facteur thymique serique) produced exclusively by thymic epithelial cells. Thymulin requires zinc for biological…

Subcutaneous injection, Intranasal
ImmuneResearch Phase

KPV

A C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (alpha-MSH) that retains potent anti-inflammatory activity…

Oral, Topical, Subcutaneous injection
AntimicrobialFDA Approved

Enfuvirtide (Fuzeon)

A 36-amino acid synthetic peptide that inhibits HIV-1 entry into CD4+ T-cells by blocking the gp41-mediated membrane fusion step. Enfuvirtide binds…

Subcutaneous injection (twice daily)
PerformanceResearch Phase

Melanotan II

A synthetic cyclic analog of alpha-melanocyte stimulating hormone (alpha-MSH) that non-selectively activates melanocortin receptors MC1R through…

Subcutaneous injection
BoneFDA Approved

Teriparatide (Forteo)

A recombinant form of the first 34 amino acids of human parathyroid hormone (PTH 1-34). When administered intermittently via daily subcutaneous…

Subcutaneous injection (daily)
BoneFDA Approved

Abaloparatide (Tymlos)

A synthetic 34-amino acid peptide analog of parathyroid hormone-related protein (PTHrP 1-34) that selectively activates the RG conformation of the…

Subcutaneous injection (daily)
BoneFDA Approved

Calcitonin

A 32-amino acid peptide hormone naturally produced by parafollicular C-cells of the thyroid gland. Calcitonin inhibits osteoclast-mediated bone…

Intranasal, Subcutaneous injection, Intramuscular injection
BoneFDA Approved

Vosoritide (Voxzogo)

A C-type natriuretic peptide (CNP) analog that acts as an agonist at the natriuretic peptide receptor B (NPR-B) on growth plate chondrocytes.…

Subcutaneous injection (daily)
RenalFDA Approved

Vasopressin (ADH)

A nine-amino acid cyclic peptide hormone (arginine vasopressin) produced in the hypothalamus and released from the posterior pituitary. Vasopressin…

Intravenous, Intramuscular injection, Subcutaneous injection
RenalFDA Approved

Desmopressin (DDAVP)

A synthetic analog of vasopressin with enhanced V2 receptor selectivity and minimal V1a vasopressor activity. Desmopressin has a deaminated cysteine…

Intranasal, Oral, Subcutaneous injection, Intravenous
RenalFDA Approved

Terlipressin

A synthetic vasopressin analog and prodrug that is cleaved by endopeptidases to release lysine-vasopressin. Terlipressin has greater V1a receptor…

Intravenous
CardiovascularFDA Approved

Eptifibatide (Integrilin)

A synthetic cyclic heptapeptide modeled after the KGD (Lys-Gly-Asp) disintegrin sequence found in the venom of the southeastern pygmy rattlesnake…

Intravenous
CardiovascularFDA Approved

Nesiritide (Natrecor)

A recombinant form of human B-type natriuretic peptide (BNP), a 32-amino acid peptide naturally produced by ventricular cardiomyocytes in response to…

Intravenous
CardiovascularFDA Approved

Angiotensin II (Giapreza)

A synthetic form of the endogenous octapeptide angiotensin II, the primary effector of the renin-angiotensin system. Angiotensin II acts on AT1…

Intravenous
HematologyFDA Approved

Bivalirudin (Angiomax)

A synthetic 20-amino acid peptide that acts as a direct thrombin inhibitor by binding both the catalytic active site and anion-binding exosite 1 of…

Intravenous
HematologyFDA Approved

Romiplostim (Nplate)

A thrombopoietin (TPO) receptor agonist consisting of a peptide sequence that binds the TPO receptor (c-Mpl) fused to an IgG1 Fc domain (peptibody).…

Subcutaneous injection (weekly)
HematologyFDA Approved

Pegcetacoplan (Empaveli)

A pegylated cyclic peptide that inhibits complement component C3, the central node of all three complement activation pathways (classical, lectin…

Subcutaneous infusion
OncologyFDA Approved

Carfilzomib (Kyprolis)

A tetrapeptide epoxyketone proteasome inhibitor that irreversibly binds the chymotrypsin-like (beta5) subunit of the 20S proteasome. By blocking…

Intravenous
OncologyFDA Approved

Bortezomib (Velcade)

A modified dipeptidyl boronic acid that reversibly inhibits the chymotrypsin-like activity of the 26S proteasome. Bortezomib disrupts the…

Subcutaneous injection, Intravenous
OncologyFDA Approved

Lutetium-177 dotatate (Lutathera)

A radiolabeled somatostatin analog consisting of the peptide DOTA-Tyr3-octreotate chelated to the beta-emitting radioisotope lutetium-177. Lutathera…

Intravenous
OncologyFDA Approved

Leuprolide (Lupron) - Oncology

A GnRH agonist used in oncology for androgen deprivation therapy (ADT) in prostate cancer and hormone suppression in premenopausal breast cancer.…

Intramuscular injection (depot), Subcutaneous injection

All 265 peptides

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