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Peptide DatabasePage 2

265 therapeutic peptides with research summaries, clinical findings, and regulatory status.

Showing 37–72 of 78 with status Research PhaseClear filters
DermatologyResearch Phase

Myristoyl Pentapeptide-17

Myristoyl Pentapeptide-17 is a lipopeptide composed of a pentapeptide sequence conjugated to myristic acid to facilitate penetration of the hair…

Topical
DermatologyResearch Phase

Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-1 is a synthetic lipopeptide comprising a tripeptide linked to palmitic acid, designed to mimic a portion of the Type I collagen…

Topical
DermatologyResearch Phase

Copper Peptide (Prezatide Copper Acetate)

Prezatide Copper Acetate is a tripeptide-copper complex, most commonly represented by the sequence Gly-His-Lys bound to a copper ion. Copper peptides…

Topical
DermatologyResearch Phase

Melitane (Acetyl Hexapeptide-1)

Acetyl Hexapeptide-1 is a synthetic hexapeptide designed to stimulate melanin synthesis by acting as an agonist at melanocortin-1 receptors on…

Topical
ImmuneResearch Phase

Splenopentin

Splenopentin is a synthetic pentapeptide (Arg-Lys-Glu-Val-Tyr) corresponding to residues 32 to 36 of the splenic hormone splenin. It modulates immune…

Subcutaneous injection, Intravenous
ImmuneResearch Phase

Bursin

Bursin is a tripeptide (Lys-His-Gly) originally isolated from the bursa of Fabricius in avian species. It promotes B-lymphocyte differentiation and…

Subcutaneous injection
ImmuneResearch Phase

Alpha-MSH

Alpha-melanocyte-stimulating hormone (alpha-MSH) is a 13-amino-acid peptide derived from proopiomelanocortin (POMC). It acts via melanocortin…

Subcutaneous injection, Intravenous
ImmuneResearch Phase

Beta-Defensin 2

Beta-defensin 2 (hBD-2) is an antimicrobial peptide of approximately 40 amino acids produced by epithelial cells in response to infection or…

Topical, Subcutaneous injection
ImmuneResearch Phase

Beta-Defensin 3

Beta-defensin 3 (hBD-3) is an antimicrobial peptide of approximately 45 amino acids with potent activity against a wide range of pathogens, including…

Topical, Subcutaneous injection
ImmuneResearch Phase

Granulysin

Granulysin is a 15-kDa antimicrobial and cytolytic protein expressed by cytotoxic T lymphocytes and natural killer cells. It disrupts microbial and…

Intravenous, Subcutaneous injection
CardiovascularResearch Phase

Atrial Natriuretic Peptide (ANP)

Atrial natriuretic peptide is a 28-amino acid endogenous hormone secreted primarily by atrial cardiomyocytes in response to atrial stretch and volume…

Endogenous
CardiovascularResearch Phase

C-type Natriuretic Peptide (CNP)

C-type natriuretic peptide is a 22-amino acid member of the natriuretic peptide family that selectively activates natriuretic peptide receptor B…

Endogenous
CardiovascularResearch Phase

Urocortin 2

Urocortin 2 is a 38-amino acid peptide member of the corticotropin-releasing factor family with selective affinity for CRF receptor 2. It exerts…

Intravenous
CardiovascularResearch Phase

Urocortin 3

Urocortin 3, also known as stresscopin, is a 38-amino acid peptide with high selectivity for CRF receptor 2. It produces vasodilation and increases…

Intravenous
CardiovascularResearch Phase

Apelin-13

Apelin-13 is a 13-amino acid endogenous peptide that represents the most potent and abundant isoform of the apelin family. It acts as the ligand for…

Intravenous
GastrointestinalResearch Phase

Glucagon Receptor Antagonist Peptides

Glucagon receptor antagonist peptides are a class of molecules designed to block the glucagon receptor and prevent glucagon-mediated hepatic glucose…

Subcutaneous injection
GastrointestinalResearch Phase

Motilin

Motilin is a 22-amino acid endogenous peptide hormone secreted by enteroendocrine cells in the duodenum and jejunum. It binds to motilin receptors on…

Intravenous
GastrointestinalResearch Phase

Gastrin

Gastrin is an endogenous peptide hormone secreted by G-cells in the gastric antrum and duodenum, existing primarily as gastrin-17 and gastrin-34. It…

Subcutaneous injection, Intravenous
GastrointestinalResearch Phase

Guanylin

Guanylin is a 15-amino acid endogenous peptide hormone that activates guanylate cyclase-C (GC-C) receptors on intestinal epithelial cells. Upon…

Endogenous peptide
PainResearch Phase

Dynorphin A

Dynorphin A is an endogenous opioid peptide of 17 amino acids that preferentially binds to and activates kappa-opioid receptors, though it also has…

Endogenous peptide
PainResearch Phase

Leu-Enkephalin

Leu-enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Leu) that functions as an endogenous opioid agonist with preferential activity at delta-opioid…

Endogenous peptide
PainResearch Phase

Met-Enkephalin

Met-enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met) that differs from leu-enkephalin only in its C-terminal amino acid. It acts as an endogenous…

Endogenous peptide
PainResearch Phase

Endomorphin-1

Endomorphin-1 is a tetrapeptide (Tyr-Pro-Trp-Phe) that exhibits highly selective agonist activity at the mu-opioid receptor, the primary target for…

Endogenous peptide
PainResearch Phase

Endomorphin-2

Endomorphin-2 is a tetrapeptide (Tyr-Pro-Phe-Phe) that, like endomorphin-1, demonstrates highly selective agonism at mu-opioid receptors. The two…

Endogenous peptide
PainResearch Phase

Nociceptin / Orphanin FQ

Nociceptin, also known as orphanin FQ, is a 17-amino acid peptide that acts as the endogenous ligand for the nociceptin/orphanin FQ peptide (NOP)…

Endogenous peptide
PainResearch Phase

Dermorphin

Dermorphin is a heptapeptide opioid agonist originally isolated from the skin of South American Phyllomedusa frogs. It exhibits high selectivity and…

Intracerebroventricular, Subcutaneous injection
PainResearch Phase

Deltorphin

Deltorphin is a heptapeptide opioid agonist also derived from Phyllomedusa frog skin secretions, characterized by high selectivity for delta-opioid…

Intracerebroventricular, Subcutaneous injection
PainResearch Phase

Neuropeptide FF

Neuropeptide FF (NPFF) is an octapeptide belonging to the RFamide family, characterized by an arginine-phenylalanine-amide motif at the C-terminus.…

Intracerebroventricular, Subcutaneous injection
AntimicrobialResearch Phase

Magainin 2

Magainin 2 is a 23-amino acid antimicrobial peptide originally isolated from the skin of the African clawed frog Xenopus laevis. It exerts…

Topical
AntimicrobialResearch Phase

Defensin HNP-1

Human neutrophil peptide 1 (HNP-1) is a 30-amino acid alpha-defensin produced by neutrophils as part of the innate immune response. It contains three…

Topical, Intravenous
AntimicrobialResearch Phase

Alpha-Defensin 5

Alpha-defensin 5 (HD5) is a 32-amino acid cationic peptide predominantly expressed by Paneth cells in the small intestinal crypts. It contains three…

Oral, Topical
AntimicrobialResearch Phase

Indolicidin

Indolicidin is a 13-amino acid antimicrobial peptide derived from bovine neutrophils, characterized by a high tryptophan content (five residues). It…

Topical
BoneResearch Phase

Osteogenic Growth Peptide (OGP)

Osteogenic Growth Peptide is a naturally occurring 14-amino acid peptide identified in serum that promotes osteoblast proliferation and…

Subcutaneous injection
BoneResearch Phase

Calcitonin Gene-Related Peptide (CGRP)

Calcitonin gene-related peptide is a 37-amino acid neuropeptide produced by alternative splicing of the calcitonin gene. CGRP acts as a potent…

Intravenous, Subcutaneous injection
LongevityResearch Phase

Klotho Peptide

Klotho is a transmembrane protein of approximately 1012 amino acids that exists in membrane-bound and secreted forms, with the soluble ectodomain…

Intravenous
LongevityResearch Phase

Sirtuin-Activating Peptides

Sirtuin-activating peptides represent a class of investigational compounds designed to enhance the enzymatic activity of sirtuins, a family of…

Subcutaneous injection

All 265 peptides

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Peptide therapies discussed on this site may not be FDA-approved for all listed indications. Individual results vary. The Peptide Association does not prescribe, diagnose, or treat any medical condition. Clinicians in our network are independently licensed practitioners; the Association reviews licensure but does not employ or directly supervise these clinicians.

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