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Peptide Database

265 therapeutic peptides with research summaries, clinical findings, and regulatory status.

Showing 1–36 of 41 with status In Clinical TrialsClear filters
RecoveryIn Clinical Trials

TB-500 (Thymosin Beta-4)

Thymosin Beta-4 is a 43-amino acid actin-sequestering protein involved in cell migration, differentiation, and tissue repair. It promotes wound…

Subcutaneous injection
MetabolicIn Clinical Trials

Retatrutide

An investigational triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. The glucagon receptor component adds…

Subcutaneous injection (weekly)
HormoneIn Clinical Trials

CJC-1295

A synthetic analog of growth hormone-releasing hormone (GHRH) with a Drug Affinity Complex (DAC) that binds to albumin, extending its half-life from…

Subcutaneous injection
HormoneIn Clinical Trials

Ipamorelin

A highly selective growth hormone secretagogue that acts on ghrelin/GHS receptors in the pituitary gland to stimulate GH release. Unlike other GH…

Subcutaneous injection
HormoneIn Clinical Trials

Kisspeptin

A neuropeptide encoded by the KISS1 gene that serves as the master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin…

Intravenous, Subcutaneous injection
HormoneIn Clinical Trials

MK-677 (Ibutamoren)

An orally bioavailable, non-peptide growth hormone secretagogue that mimics the action of ghrelin at the GHS-R1a receptor. MK-677 stimulates…

Oral
ReproductiveIn Clinical Trials

Carbetocin

A long-acting synthetic analog of oxytocin with a modified disulfide bridge that confers resistance to enzymatic degradation. Carbetocin has a…

Intravenous, Intramuscular injection
LongevityIn Clinical Trials

NAD+ Precursors (NMN)

Nicotinamide mononucleotide (NMN) is a direct biosynthetic precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular…

Oral, Intravenous, Sublingual
LongevityIn Clinical Trials

SS-31 (Elamipretide)

A mitochondria-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that selectively concentrates in the inner mitochondrial membrane by binding to…

Subcutaneous injection, Intravenous
GastrointestinalIn Clinical Trials

Larazotide

A synthetic octapeptide derived from Vibrio cholerae zonula occludens toxin that acts as a tight junction regulator. Larazotide acetate modulates…

Oral
PainIn Clinical Trials

ARA-290

A synthetic 11-amino acid peptide derived from the structure of erythropoietin (EPO) that selectively activates the innate repair receptor (IRR), a…

Subcutaneous injection, Intravenous
MetabolicIn Clinical Trials

Orforglipron

Orforglipron is a non-peptide, oral small-molecule glucagon-like peptide-1 receptor (GLP-1R) agonist designed to overcome the need for injectable…

Oral
MetabolicIn Clinical Trials

Mazdutide

Mazdutide is a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist delivered as a synthetic peptide. By co-activating both receptors…

Subcutaneous injection
MetabolicIn Clinical Trials

Survodutide

Survodutide is a dual agonist targeting both the glucagon-like peptide-1 (GLP-1) and glucagon receptors, formulated as a peptide for subcutaneous…

Subcutaneous injection
MetabolicIn Clinical Trials

CagriSema

CagriSema is a fixed-ratio combination of cagrilintide, an amylin analog, and semaglutide, a GLP-1 receptor agonist, both delivered as peptides via…

Subcutaneous injection
MetabolicIn Clinical Trials

Amycretin

Amycretin is a dual agonist targeting both the amylin and calcitonin receptors, designed as a peptide therapeutic for obesity. Amylin receptor…

Subcutaneous injection
MetabolicIn Clinical Trials

Efinopegdutide

Efinopegdutide is a long-acting dual agonist of the GLP-1 and glucagon receptors, utilizing PEGylation to extend half-life and enable once-weekly…

Subcutaneous injection
MetabolicIn Clinical Trials

Danuglipron

Danuglipron is an oral, non-peptide small-molecule agonist of the GLP-1 receptor developed to provide convenient daily dosing for type 2 diabetes and…

Oral
MetabolicIn Clinical Trials

Ecnoglutide

Ecnoglutide is a long-acting GLP-1 receptor agonist peptide designed for once-weekly subcutaneous administration. It acts by enhancing…

Subcutaneous injection
MetabolicIn Clinical Trials

Cotadutide

Cotadutide is a dual agonist of the GLP-1 and glucagon receptors formulated as a peptide for subcutaneous injection. It is designed to harness…

Subcutaneous injection
MetabolicIn Clinical Trials

Glepaglutide

Glepaglutide is a long-acting GLP-2 receptor agonist peptide developed for the treatment of short bowel syndrome. GLP-2 promotes intestinal growth…

Subcutaneous injection
MetabolicIn Clinical Trials

Apraglutide

Apraglutide is a long-acting glucagon-like peptide-2 (GLP-2) receptor agonist designed to promote intestinal growth and improve absorption in…

Subcutaneous injection
MetabolicIn Clinical Trials

Pemvidutide

Pemvidutide is a dual receptor agonist targeting both glucagon-like peptide-1 (GLP-1) and glucagon receptors, designed to combine the insulinotropic…

Subcutaneous injection
MetabolicIn Clinical Trials

Cagrilintide

Cagrilintide is a long-acting amylin analogue engineered with structural modifications to extend half-life and enable once-weekly dosing for the…

Subcutaneous injection
RecoveryIn Clinical Trials

Nexagon (Gap Junction Peptide)

Nexagon is a synthetic peptide designed to transiently modulate gap junction intercellular communication by mimicking a segment of the connexin…

Topical
CognitiveIn Clinical Trials

Intranasal Insulin

Intranasal insulin involves the administration of regular human insulin via nasal spray to target central nervous system insulin receptors without…

Intranasal
CognitiveIn Clinical Trials

Cortexin

Cortexin is a complex polypeptide mixture extracted from bovine cerebral cortex, containing a range of neuropeptides and neurotrophic factors with…

Intramuscular injection
CardiovascularIn Clinical Trials

Ularitide (Urodilatin)

Ularitide is a synthetic 32-amino acid peptide analogue of urodilatin, a natriuretic peptide produced in renal tubular cells. It binds to guanylyl…

Intravenous
OncologyIn Clinical Trials

Buserelin (Suprefact)

Buserelin is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH) that acts as a potent GnRH agonist. It binds with high…

Subcutaneous injection, Intranasal
OncologyIn Clinical Trials

Vantictumab

Vantictumab is a fully human monoclonal antibody that targets multiple Frizzled receptors involved in the Wnt signaling pathway. By blocking Frizzled…

Intravenous
OncologyIn Clinical Trials

Plitidepsin (Aplidin)

Plitidepsin is a cyclic depsipeptide originally isolated from the Mediterranean tunicate Aplidium albicans and now produced synthetically. It targets…

Intravenous
OncologyIn Clinical Trials

Melphalan Flufenamide (Pepaxto)

Melphalan flufenamide is a first-in-class peptide-drug conjugate that links the alkylating agent melphalan to a dipeptide carrier. The dipeptide…

Intravenous
GastrointestinalIn Clinical Trials

Peptide YY (PYY 3-36)

Peptide YY 3-36 is a 34-amino acid endogenous peptide hormone secreted by L-cells in the distal small intestine and colon in response to nutrient…

Intravenous, Intranasal
GastrointestinalIn Clinical Trials

Ghrelin Receptor Antagonists

Ghrelin receptor antagonists are a class of peptides and peptidomimetics designed to block the growth hormone secretagogue receptor (GHSR), also…

Subcutaneous injection, Oral
GastrointestinalIn Clinical Trials

Uroguanylin (Dolcanatide)

Uroguanylin is a 16-amino acid endogenous peptide structurally related to guanylin that also activates guanylate cyclase-C receptors in the…

Oral
AntimicrobialIn Clinical Trials

Pexiganan (MSI-78)

Pexiganan is a 22-amino acid synthetic analog of magainin 2 designed to enhance antimicrobial potency and proteolytic stability. It disrupts…

Topical

All 265 peptides

Complete index, every profile, one click away.

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Peptide therapies discussed on this site may not be FDA-approved for all listed indications. Individual results vary. The Peptide Association does not prescribe, diagnose, or treat any medical condition. Clinicians in our network are independently licensed practitioners; the Association reviews licensure but does not employ or directly supervise these clinicians.

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