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The compound database

Peptide Database

264 therapeutic peptides with research summaries, clinical findings, and regulatory status. Every claim is cited.

FDA-approved
90
FDA-approved
Awaiting FDA
8
Awaiting FDA
No lawful pathway
166
No lawful pathway
1–13 of 13 · Metabolic · FDA ApprovedClear filters
  1. 001

    Semaglutide (Ozempic/Wegovy)

    A glucagon-like peptide-1 receptor agonist (GLP-1 RA) that differs from native GLP-1 by two amino acid substitutions (about 94% sequence identity) plus a fatty…

    Metabolic · FDA Approved · Subcutaneous injection (weekly), Oral (daily - Rybelsus)

    FDA-approved
  2. 002

    Tirzepatide (Mounjaro/Zepbound)

    A once-weekly dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. Tirzepatide activates both incretin pathways, and in…

    Metabolic · FDA Approved · Subcutaneous injection (weekly)

    FDA-approved
  3. 003

    Liraglutide (Saxenda/Victoza)

    A GLP-1 receptor agonist with 97% homology to native GLP-1, modified with a 16-carbon fatty acid chain that binds albumin and protects against DPP-4…

    Metabolic · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  4. 004

    Exenatide (Byetta/Bydureon)

    A synthetic version of exendin-4, a 39-amino acid peptide originally isolated from the venom of the Gila monster lizard (Heloderma suspectum). Exenatide shares…

    Metabolic · FDA Approved · Subcutaneous injection (twice daily or weekly extended-release)

    FDA-approved
  5. 005

    Glucagon

    A 29-amino acid peptide hormone produced by alpha cells of the pancreatic islets of Langerhans. Glucagon acts on the liver via the glucagon receptor (GCGR), a…

    Metabolic · FDA Approved · Subcutaneous injection, Intramuscular injection, Intranasal

    FDA-approved
  6. 006

    Pramlintide (Symlin)

    A synthetic analog of amylin (islet amyloid polypeptide), a 37-amino acid peptide hormone co-secreted with insulin from pancreatic beta cells. Pramlintide has…

    Metabolic · FDA Approved · Subcutaneous injection (before meals)

    FDA-approved
  7. 007

    Dulaglutide (Trulicity)

    A long-acting GLP-1 receptor agonist consisting of a GLP-1 analog fused to a modified human IgG4 Fc fragment, a design that retained full receptor activity…

    Metabolic · FDA Approved · Subcutaneous injection (weekly)

    FDA-approved
  8. 008

    Lixisenatide (Adlyxin)

    A selective GLP-1 receptor agonist derived from exendin-4 with a modified C-terminal tail containing six lysine residues. Lixisenatide increases…

    Metabolic · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  9. 009

    Setmelanotide (Imcivree)

    A cyclic peptide melanocortin-4 receptor (MC4R) agonist designed to restore MC4R signaling in patients with obesity caused by genetic defects in the…

    Metabolic · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  10. 010

    Orforglipron

    Orforglipron is a non-peptide, oral small-molecule glucagon-like peptide-1 receptor (GLP-1R) agonist developed as an alternative to injectable GLP-1 drugs. It…

    Metabolic · FDA Approved · Oral

    FDA-approved
  11. 011

    Teduglutide (Gattex)

    Teduglutide is a recombinant analogue of human glucagon-like peptide-2 (GLP-2) comprising 33 amino acids with a single amino acid substitution that confers…

    Metabolic · FDA Approved · Subcutaneous injection

    FDA-approved
  12. 012

    Albiglutide (Tanzeum)

    Albiglutide is a GLP-1 receptor agonist made of modified human GLP-1 sequences fused to human albumin, giving it an elimination half-life of about 5 days that…

    Metabolic · FDA Approved · Subcutaneous injection

    FDA-approved
  13. 013

    Enlicitide

    Enlicitide (enlicitide decanoate, formerly MK-0616) is an oral macrocyclic peptide that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9)…

    Metabolic · FDA Approved · Oral

    FDA-approved

Index · all 264 peptides, A–Z

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