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The compound database

Peptide Databasepage 7

264 therapeutic peptides with research summaries, clinical findings, and regulatory status. Every claim is cited.

FDA-approved
90
FDA-approved
Awaiting FDA
8
Awaiting FDA
No lawful pathway
166
No lawful pathway
217–252 of 264
  1. 217

    Dermorphin

    Dermorphin is a heptapeptide opioid agonist originally isolated from the skin of South American Phyllomedusa frogs. It is a selective mu-opioid receptor…

    Pain · Investigational · Intracerebroventricular, Subcutaneous injection

    No lawful pathway
  2. 218

    Deltorphin

    Deltorphin refers to a class of highly selective delta-opioid heptapeptides from the skin of the Amazonian frogs Phyllomedusa sauvagei and Phyllomedusa…

    Pain · Research Phase · Intracerebroventricular, Subcutaneous injection

    No lawful pathway
  3. 219

    Neuropeptide FF

    Neuropeptide FF (NPFF) is a member of the RFamide peptide family, characterized by an arginine-phenylalanine-amide motif at the C-terminus. It acts on the G…

    Pain · Research Phase · Intracerebroventricular, Subcutaneous injection

    No lawful pathway
  4. 220

    Magainin 2

    Magainin 2 is one of a family of 23-amino acid antimicrobial peptides isolated from the skin of the African clawed frog Xenopus laevis. The magainins are water…

    Antimicrobial · Research Phase · Topical

    No lawful pathway
  5. 221

    Pexiganan (MSI-78)

    Pexiganan is a 22-amino acid synthetic analog of magainin 2. It is a cationic membrane-active peptide with broad-spectrum antibacterial activity, and it was…

    Antimicrobial · Investigational · Topical

    No lawful pathway
  6. 222

    Omiganan

    Omiganan is a synthetic cationic antimicrobial peptide derived from indolicidin, a naturally occurring peptide from bovine neutrophils. It acts by disrupting…

    Antimicrobial · In Clinical Trials · Topical

    No lawful pathway
  7. 223

    Iseganan (IB-367)

    Iseganan is a synthetic analog of protegrin, a naturally occurring antimicrobial peptide found in porcine leukocytes, with broad-spectrum microbicidal activity…

    Antimicrobial · Investigational · Oral rinse

    No lawful pathway
  8. 224

    Defensin HNP-1

    Human neutrophil peptide 1 (HNP-1) is an alpha-defensin, one of three alpha-defensins that human neutrophils contain in large amounts. Defensins are small…

    Antimicrobial · Research Phase · Topical, Intravenous

    No lawful pathway
  9. 225

    Alpha-Defensin 5

    Alpha-defensin 5, also called human defensin 5 or HD-5, is an alpha-defensin secreted by Paneth cells, the specialized epithelia of the small intestinal crypt.…

    Antimicrobial · Research Phase · Oral, Topical

    No lawful pathway
  10. 226

    Lactoferricin

    Lactoferricin is an antimicrobial peptide released by pepsin-mediated cleavage of lactoferrin, an iron-binding glycoprotein found in milk and mucosal…

    Antimicrobial · Investigational · Oral, Topical

    No lawful pathway
  11. 227

    Nisin

    Nisin is a polycyclic antibacterial peptide (lantibiotic) produced by Lactococcus lactis. It acts against Gram-positive bacteria, binding lipid II, the…

    Antimicrobial · Investigational · Topical, Oral

    No lawful pathway
  12. 228

    Gramicidin S

    Gramicidin S is a cyclic decapeptide antibiotic consisting of two identical pentapeptide sequences joined in a ring. It kills bacteria by disrupting cell…

    Antimicrobial · Investigational · Topical

    No lawful pathway
  13. 229

    Polymyxin B

    Polymyxin B is a cyclic lipopeptide antibiotic consisting of a heptapeptide ring and a tripeptide side chain acylated with a fatty acid tail. It binds…

    Antimicrobial · FDA Approved · Intravenous, Intrathecal, Topical

    FDA-approved
  14. 230

    Colistin (Polymyxin E)

    Colistin, also known as polymyxin E, is a cyclic polypeptide antibiotic structurally similar to polymyxin B. It disrupts the Gram-negative outer membrane by…

    Antimicrobial · FDA Approved · Intravenous, Intramuscular, Inhalation

    FDA-approved
  15. 231

    Indolicidin

    Indolicidin is a 13-residue antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils, unusually rich in tryptophan and proline.…

    Antimicrobial · Research Phase · Topical

    No lawful pathway
  16. 232

    PTH (1-34) Analogs

    This class includes teriparatide, which corresponds to the 34 N-terminal amino acids of human parathyroid hormone, and abaloparatide, which the FDA label…

    Bone · FDA Approved · Subcutaneous injection

    FDA-approved
  17. 233

    Sclerostin Antibodies (Romosozumab)

    Romosozumab is a humanized monoclonal antibody that binds and inhibits sclerostin, a glycoprotein produced by osteocytes that negatively regulates Wnt…

    Bone · FDA Approved · Subcutaneous injection

    FDA-approved
  18. 234

    Osteogenic Growth Peptide (OGP)

    Osteogenic growth peptide is a naturally occurring 14-amino acid peptide identified in serum that has been studied for its effects on osteoblast proliferation…

    Bone · Research Phase · Subcutaneous injection

    No lawful pathway
  19. 235

    BMP-2 (Bone Morphogenetic Protein-2)

    BMP-2 is a member of the transforming growth factor-beta superfamily and functions as a homodimeric protein. It binds type I and type II serine and threonine…

    Bone · FDA Approved · Surgical implantation

    FDA-approved
  20. 236

    BMP-7 (Osteogenic Protein-1)

    BMP-7, also known as osteogenic protein-1, is a bone morphogenetic protein with a mature homodimeric structure. Like other BMPs it signals through serine and…

    Bone · FDA Approved · Surgical implantation

    FDA-approved
  21. 237

    Calcitonin Gene-Related Peptide (CGRP)

    Calcitonin gene-related peptide is a neuropeptide produced by alternative splicing of the calcitonin gene, with CGRP-alpha and CGRP-beta isoforms. It is a…

    Bone · Research Phase · Intravenous, Subcutaneous injection

    No lawful pathway
  22. 238

    Gonadotropin Releasing Hormone (GnRH) Agonists

    Gonadotropin-releasing hormone agonists are synthetic analogues of native GnRH that initially stimulate and then, with continuous exposure, downregulate…

    Longevity · FDA Approved · Subcutaneous injection, Intramuscular injection, Subcutaneous implant, Intranasal

    FDA-approved
  23. 239

    Klotho Peptide

    Klotho is a protein that exists in membrane-bound and secreted forms, with the soluble ectodomain acting as a circulating factor. It serves as a coreceptor for…

    Longevity · Research Phase · Intravenous

    No lawful pathway
  24. 240

    Sirtuin-Activating Peptides

    Sirtuin-activating peptides are a proposed class of compounds intended to enhance the activity of sirtuins, a family of NAD-dependent deacetylases implicated…

    Longevity · Research Phase · Subcutaneous injection

    No lawful pathway
  25. 241

    Mitochondrial-Targeted Peptides (MTP)

    Mitochondrial-targeted peptides are short synthetic sequences designed to localize to mitochondria and limit oxidative damage and organelle dysfunction. The…

    Longevity · FDA Approved · Subcutaneous injection, Intravenous

    FDA-approved
  26. 242

    Gerontin (Pineal Gland Extract)

    Gerontin is a name applied to peptide fractions derived from pineal gland extracts in Russian gerontology research. No publications indexed in PubMed under…

    Longevity · Research Phase · Subcutaneous injection

    No lawful pathway
  27. 243

    Vilon (Lys-Glu)

    Vilon is a synthetic dipeptide consisting of lysine and glutamic acid (Lys-Glu) developed as part of the Khavinson bioregulator peptide research program. The…

    Longevity · Investigational · Subcutaneous injection, Oral

    No lawful pathway
  28. 244

    Bioregulator Peptides (Khavinson)

    Bioregulator peptides are a class of short synthetic peptides, typically 2 to 4 amino acids in length, developed by Russian researcher Vladimir Khavinson based…

    Longevity · Investigational · Subcutaneous injection, Oral, Intramuscular injection

    No lawful pathway
  29. 245

    IGF-1 LR3 (Long-Arg3)

    IGF-1 LR3 is a synthetic analogue of insulin-like growth factor 1 with a 13-amino-acid N-terminal extension and arginine substituted for glutamate at position…

    Performance · Research Phase · Subcutaneous injection

    No lawful pathway
  30. 246

    IGF-1 DES (1-3)

    IGF-1 DES (1-3) is a truncated form of insulin-like growth factor 1 lacking the first three N-terminal residues, glycine-proline-glutamate, and it occurs…

    Performance · Research Phase · Subcutaneous injection

    No lawful pathway
  31. 247

    MGF (Mechano Growth Factor)

    Mechano Growth Factor is the name given to a splice variant of the IGF-1 gene, IGF-1Eb in rodents and IGF-1Ec in humans, that is upregulated in muscle after…

    Performance · Research Phase · Intramuscular injection

    No lawful pathway
  32. 248

    PEG-MGF

    PEG-MGF is described by its vendors as a pegylated derivative of Mechano Growth Factor, with polyethylene glycol added in the expectation that it slows renal…

    Performance · Research Phase · Subcutaneous injection

    No lawful pathway
  33. 249

    Follistatin-344

    Follistatin-344 is an alternatively spliced isoform of follistatin, a secreted binding protein that neutralizes myostatin, activin and other TGF-beta…

    Performance · Investigational · Intramuscular injection, Gene delivery

    No lawful pathway
  34. 250

    ACE-031 (Ramatercept)

    ACE-031 is a recombinant fusion protein combining the extracellular domain of activin receptor type IIB with a human IgG1 Fc domain. The soluble receptor acts…

    Performance · Investigational · Subcutaneous injection

    No lawful pathway
  35. 251

    Nafarelin (Synarel)

    Nafarelin is a synthetic decapeptide analogue of gonadotropin-releasing hormone with substitutions that enhance receptor affinity and metabolic stability.…

    Reproductive · FDA Approved · Intranasal

    FDA-approved
  36. 252

    Choriogonadotropin Alfa (Ovidrel)

    Choriogonadotropin alfa is a recombinant human chorionic gonadotropin produced in Chinese hamster ovary cells. The heterodimeric glycoprotein binds the LH/hCG…

    Reproductive · FDA Approved · Subcutaneous injection

    FDA-approved

Index · all 264 peptides, A–Z

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Peptide therapies discussed on this site may not be FDA-approved for all listed indications. Individual results vary. The Peptide Association does not prescribe, diagnose, or treat any medical condition. Clinicians in our network are independently licensed practitioners; the Association checks each clinician’s NPI record but does not employ or directly supervise these clinicians.

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