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The compound database

Peptide Databasepage 2

264 therapeutic peptides with research summaries, clinical findings, and regulatory status. Every claim is cited.

FDA-approved
90
FDA-approved
Awaiting FDA
8
Awaiting FDA
No lawful pathway
166
No lawful pathway
37–72 of 82 · InvestigationalClear filters
  1. 037

    Argireline (Acetyl Hexapeptide-8)

    Argireline is a synthetic six amino acid peptide (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) patterned on the N-terminal end of the SNAP-25 protein and designed to mimic…

    Dermatology · Investigational · Topical

    No lawful pathway
  2. 038

    Matrixyl (Palmitoyl Pentapeptide-4)

    Matrixyl is a lipopeptide composed of the pentapeptide sequence Lys-Thr-Thr-Lys-Ser (KTTKS) attached to palmitic acid to improve skin delivery. In vitro work…

    Dermatology · Investigational · Topical

    No lawful pathway
  3. 039

    Matrixyl 3000

    Matrixyl 3000 is a proprietary combination of two lipopeptides, palmitoyl tripeptide-1 (Pal-GHK) and palmitoyl tetrapeptide-7 (Pal-GQPR), marketed to support…

    Dermatology · Investigational · Topical

    No lawful pathway
  4. 040

    Matrixyl Synthe'6 (Palmitoyl Tripeptide-38)

    Palmitoyl tripeptide-38 is a synthetic lipopeptide described as a matrix-repair peptide for photoaged skin. Its supplier markets it as stimulating synthesis of…

    Dermatology · Investigational · Topical

    No lawful pathway
  5. 041

    SYN-AKE (Dipeptide Diaminobutyroyl Benzylamide Diacetate)

    SYN-AKE is a synthetic dipeptide derivative modeled on waglerin-1, a peptide from Temple viper venom that blocks the adult muscle-type nicotinic acetylcholine…

    Dermatology · Investigational · Topical

    No lawful pathway
  6. 042

    SNAP-8 (Acetyl Octapeptide-3)

    SNAP-8 is an elongated derivative of Argireline, consisting of eight amino acids (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) intended to mimic the SNAP-25…

    Dermatology · Investigational · Topical

    No lawful pathway
  7. 043

    Leuphasyl (Pentapeptide-18)

    Leuphasyl is a synthetic pentapeptide (Tyr-D-Ala-Gly-Phe-Leu) modeled on the N-terminal sequence of enkephalin. It is described as a neuromodulatory peptide…

    Dermatology · Investigational · Topical

    No lawful pathway
  8. 044

    Rigin (Palmitoyl Tetrapeptide-7)

    Rigin is the tetrapeptide Gly-Gln-Pro-Arg, originally identified as a tuftsin-like fragment of human immunoglobulin G with phagocytosis-stimulating activity…

    Dermatology · Investigational · Topical

    No lawful pathway
  9. 045

    Biopeptide CL (Palmitoyl Tripeptide-5)

    Palmitoyl Tripeptide-5 is a synthetic lipopeptide consisting of a tripeptide sequence conjugated to palmitic acid to improve skin delivery. Its suppliers…

    Dermatology · Investigational · Topical

    No lawful pathway
  10. 046

    Decorinyl (Tripeptide-10 Citrulline)

    Decorinyl (tripeptide-10 citrulline) is a synthetic tetrapeptide designed to mimic the collagen-binding sites of decorin, a small proteoglycan that regulates…

    Dermatology · Investigational · Topical

    No lawful pathway
  11. 047

    Copper Peptide (Prezatide Copper Acetate)

    Prezatide copper acetate is the copper complex of the tripeptide glycyl-histidyl-lysine (GHK-Cu), a peptide originally isolated from human plasma. In…

    Dermatology · Investigational · Topical

    No lawful pathway
  12. 048

    Thymogen (Glutamyl-Tryptophan)

    Thymogen is a synthetic dipeptide consisting of L-glutamic acid and L-tryptophan (L-Glu-L-Trp), developed in Russia as a synthetic analog of the thymus extract…

    Immune · Investigational · Subcutaneous injection, Topical

    No lawful pathway
  13. 049

    Thymostimulin (TP-1)

    Thymostimulin (TP-1) is a partially purified extract of calf thymus consisting of a mixture of polypeptides. It is thought to promote T-lymphocyte maturation…

    Immune · Investigational · Intramuscular injection, Subcutaneous injection

    No lawful pathway
  14. 050

    Splenopentin

    Splenopentin (SP-5) is a synthetic pentapeptide (Arg-Lys-Glu-Val-Tyr) corresponding to residues 32 to 36 of the splenic protein splenin. It differs from the…

    Immune · Investigational · Subcutaneous injection, Intravenous

    No lawful pathway
  15. 051

    Imuthiol (Diethyldithiocarbamate)

    Imuthiol (ditiocarb sodium) is the sodium salt of diethyldithiocarbamate, a small sulfur-containing molecule rather than a peptide, which was explored as an…

    Immune · Investigational · Intravenous, Oral

    No lawful pathway
  16. 052

    Alpha-MSH

    Alpha-melanocyte-stimulating hormone (alpha-MSH) is a 13-amino-acid peptide produced from proopiomelanocortin (POMC). Acting through melanocortin receptors, it…

    Immune · Investigational · Subcutaneous injection, Intravenous

    No lawful pathway
  17. 053

    Serelaxin (Relaxin-2)

    Serelaxin is a recombinant form of human relaxin-2, a vasodilator peptide hormone that contributes to cardiovascular and renal adaptations during pregnancy. It…

    Cardiovascular · Investigational · Intravenous

    No lawful pathway
  18. 054

    Carperitide (h-ANP)

    Carperitide is a recombinant form of human atrial natriuretic peptide (alpha-human A-type natriuretic peptide), given intravenously. It activates guanylyl…

    Cardiovascular · Investigational · Intravenous

    No lawful pathway
  19. 055

    Ularitide (Urodilatin)

    Ularitide is a synthetic form of urodilatin, a natriuretic peptide produced in kidney tubular cells. Like other natriuretic peptides it acts on guanylyl…

    Cardiovascular · Investigational · Intravenous

    No lawful pathway
  20. 056

    Atrial Natriuretic Peptide (ANP)

    Atrial natriuretic peptide is a 28-amino acid hormone secreted mainly by atrial cardiomyocytes, one of the two classic cardiac natriuretic peptides along with…

    Cardiovascular · Investigational · Endogenous

    No lawful pathway
  21. 057

    Urocortin 1

    Urocortin 1 is a 40-amino acid peptide of the corticotropin-releasing factor (CRF) family that binds both CRF receptor 1 and CRF receptor 2, so unlike…

    Cardiovascular · Investigational · Intravenous

    No lawful pathway
  22. 058

    Urocortin 2

    Urocortin 2 is a 38-amino acid member of the corticotropin-releasing factor family that is selective for CRF receptor 2. In the heart this receptor mediates…

    Cardiovascular · Investigational · Intravenous

    No lawful pathway
  23. 059

    Urocortin 3

    Urocortin 3, also known as stresscopin, is a 38-amino acid peptide selective for CRF receptor 2. It produces vasodilation and increases cardiac output, and it…

    Cardiovascular · Investigational · Intravenous

    No lawful pathway
  24. 060

    Adrenomedullin

    Adrenomedullin is a 52-amino acid peptide produced by vascular endothelial and smooth muscle cells with potent blood-pressure-lowering activity. It signals…

    Cardiovascular · Investigational · Intravenous

    No lawful pathway
  25. 061

    Angiotensin (1-7)

    Angiotensin (1-7) is a seven-amino acid peptide of the renin-angiotensin system, generated from angiotensin II by ACE2 or from angiotensin I by endopeptidases…

    Cardiovascular · Investigational · Subcutaneous injection, Intravenous, Oral

    No lawful pathway
  26. 062

    Apelin-13

    Apelin-13 is a 13-amino acid endogenous peptide and one of the most potent isoforms of the apelin family. It is a ligand for the APJ (apelin) receptor, a G…

    Cardiovascular · Investigational · Intravenous

    No lawful pathway
  27. 063

    Vapreotide

    Vapreotide is a synthetic octapeptide analogue of somatostatin with a receptor-binding profile that differs from that of octreotide. Like other somatostatin…

    Oncology · Investigational · Subcutaneous injection, Intravenous

    No lawful pathway
  28. 064

    Vantictumab

    Vantictumab (OMP-18R5) is a fully human monoclonal antibody, not a peptide, that inhibits Wnt pathway signaling by binding Frizzled receptors 1, 2, 5, 7, and…

    Oncology · Investigational · Intravenous

    No lawful pathway
  29. 065

    Motilin

    Motilin is a 22-amino acid peptide hormone released from endocrine cells of the duodenal mucosa at roughly 100-minute intervals during fasting, and it is a key…

    Gastrointestinal · Investigational · Intravenous

    No lawful pathway
  30. 066

    Gastrin

    Gastrin is a peptide hormone made mainly in antroduodenal G-cells, with gastrin-34 and gastrin-17 as the major forms in tissue and plasma. It acts on the CCK2…

    Gastrointestinal · Investigational · Subcutaneous injection, Intravenous

    No lawful pathway
  31. 067

    Uroguanylin (Dolcanatide)

    Uroguanylin is a 16-amino acid peptide related to guanylin that activates guanylate cyclase-C (GC-C) receptors in the intestinal epithelium. Like guanylin, it…

    Gastrointestinal · Investigational · Oral

    No lawful pathway
  32. 068

    Dynorphin A

    Dynorphin A is a 17-amino acid endogenous opioid peptide derived from prodynorphin that preferentially activates kappa-opioid receptors. Dynorphins are…

    Pain · Investigational · Endogenous peptide

    No lawful pathway
  33. 069

    Met-Enkephalin

    Met-enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met) that differs from leu-enkephalin only in its C-terminal amino acid. Enkephalins are regarded as…

    Pain · Investigational · Endogenous peptide

    No lawful pathway
  34. 070

    Nociceptin / Orphanin FQ

    Nociceptin, also known as orphanin FQ (N/OFQ), is a 17-amino acid peptide identified in 1995 as the endogenous ligand of the opioid receptor-like ORL1…

    Pain · Investigational · Endogenous peptide

    No lawful pathway
  35. 071

    Conantokin-G

    Conantokin-G is a 17-amino acid peptide from the venom of the cone snail Conus geographus that acts as an NMDA receptor antagonist. In cells expressing defined…

    Pain · Investigational · Intrathecal, Intravenous

    No lawful pathway
  36. 072

    Dermorphin

    Dermorphin is a heptapeptide opioid agonist originally isolated from the skin of South American Phyllomedusa frogs. It is a selective mu-opioid receptor…

    Pain · Investigational · Intracerebroventricular, Subcutaneous injection

    No lawful pathway

Index · all 264 peptides, A–Z

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